![]() If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.Ĭopyright 1996-2018 Cerner Multum, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. ![]() Drug information contained herein may be time sensitive. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Midazolam is a prescription medication used to treat the symptoms of status epilepticus, sedation of intubated or ventilated patients, anesthesia and. Multiple dosing or continuous infusion: Expect longer duration of action and accumulation based on patient response, dosage reduction likely to be necessary.Every effort has been made to ensure that the information provided by Cerner Multum, Inc. Hepatic Dose : Single dose (eg, induction): No dosage adjustment recommended patients with hepatic impairment may be more sensitive compared to patients without hepatic impairment anticipate longer duration of action. Midazolam is used to produce sleepiness or drowsiness and to relieve anxiety before surgery or certain procedures. Only bolus doses, not continuous infusionĭose in Patients undergoing Renal Replacement Therapies Sedatives that are commonly used in the ICU are the benzodiazepines midazolam and lorazepam (and to a lesser extent, diazepam), the short-acting intravenous anesthetic agent propofol, and. Use sparingly and titrate according to response. Renal Dose : Dose in Renal Impairment GFR (mL/min) Opiates, Anticonvulsants, Sedative Antihistamines, Antipsychotics, Antidepressants and other Anxiolytic/Sedative agents: Enhancement of central depressive effect may occur. Theophylline, Carbamazepine and Phenytoin: May antagonize the sedative effects of benzodiazepines. ![]() is an actual patient living with seizure clusters. Learn more about this rescue medication Eva W. ![]() Grapefruit juice: Can increase the bioavailability of oral midazolam. NAYZILAM ® (midazolam) nasal spray, CIV is a prescription medicine used for the short-term treatment of seizure clusters (also known as acute repetitive seizures) in patients 12 years of age and older. ritonavir: Markedly raise the plasma concentration of midazolam thereby increasing the sedative and amnesic effects.ĭiltiazem and Verapamil: Markedly increase the plasma levels and the effects of midazolam. By continuing to view the drug information, you agree to abide by such terms of use. Itraconazole, Ketoconazole, Efavirenz, Nelfinavir, Saquinavir. versed home drugs a-z list The display and use of drug information on this site is subject to express terms of use. Interaction :Įrythromycin and other Macrolide Antibiotics, Quinupristin/Dalfopristin and Cimetidine: Inhibit the metabolism of midazolam resulting in reduced clearance, prolonged half-life, and increased volume of distribution producing raised and prolonged plasma midazolam concentrations resulting in profound sedation. Withdrawal symptoms on long term usage: muscle cramps, tremor, irritability, convulsions and perceptual distortions. Midazolam injection should not be administered by rapid injection in the neonatal population as severe hypotension and seizures have been reported. Decreased respiratory rate and apnea, drowsiness, seizure like activity, nausea/vomiting, cough, pain at injection site, ataxia, irritability, light-headedness, dysarthria, disinhibition, confusion, hangover, headache, dizziness, blurred vision, depression and hallucinations. ![]()
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